. Author manuscript; available in PMC: 2017 May 1.

Published in final edited form as: Neurotoxicol Teratol. 2016 Mar 5;55:1–7. doi: 10.1016/j.ntt.2016.02.006

Table 1.

Comparison of fluoxetine effects during and after the two year dosing period. Veh=vehicle, Flx=fluoxetine. N=16/group, except N=14 for the vehicle group for the 1 y post-dosing session.

		Session
		1 y dosing	2 y dosing	1 y post-dosing
Nighttime active periods (#)	Veh	52±2	54±2	54±3
Nighttime active periods (#)	Flx	55±1^§	58±2	63±2^*
Nighttime rest duration (min)	Veh	779±34	839±35	783±35
Nighttime rest duration (min)	Flx	763±20	793±27	674±33^*
Time to first rest period at night (min)		29±3 23±3	39±4 32±4	49±4 40±3
Daytime rest duration (min)	Veh	32±8	99±12	175±20
Daytime rest duration (min)	Flx	70±16^*	123±14	161±19
Daytime activity during rest periods (activity counts)	Veh	4.5±0.5	5.6±0.4	3.1 ±0.2
Daytime activity during rest periods (activity counts)	Flx	3.8±0.5	4.6±0.2^*	2.4±0.1^**

^§

fluoxetine*MAOA interaction p=.03, hi-MAOA Flx vs Veh p=.02

p<.05,

^**

p<.02 main effect of fluoxetine