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. Author manuscript; available in PMC: 2017 Jun 5.
Published in final edited form as: J Mol Biol. 2016 Apr 15;428(11):2430–2445. doi: 10.1016/j.jmb.2016.04.009

Figure 7. Model for SRPK1-Dependent Directional Phosphorylation and SRSF1 Nuclear Import.

Figure 7

RRM2-RS1 interactions direct SRPK1 to C-terminal end of RS1 for efficient, directional phosphorylation driven by the docking groove. Severing RRM2-RS1 interactions by mutation leads to non-directional phosphorylation, increased accessibility of RS domain to protein phosphatases (PPases) and enhanced protease sensitivity (box).