(A) RT-PCR amplification of a 151-bp GPR30 fragment in soleus muscle. Lane 1, marker; lane 2, soleus muscle; lane 3, negative control (without cDNA). (B) Western blot of soleus muscle showing a single band corresponding to the appropriate molecular weight of GPR30 (~50 kDa). Lane 1, marker; lane 2-3, soleus muscle samples. (C) GPR30 mRNA level, determined by real-time PCR, in extensor digitorum longus (EDL) and gastrocnemius (GAS) of sham-operated and ovariectomized (OVX) female F344BN rats treated with vehicle or G1 for 2 months. Values are mean±SEM; *P<0.05 vs. sham; #P<0.05 vs. OVX-V. n=7/group.