Figure 1.

The canonical Notch signaling pathway. The interaction between Notch and its ligands from neighboring cells results in two successive cleavage event: cleavage at site S2 by ADAM protease and subsequent intramembranous cleavage at S3 by γ‐secretase complex. This ligand‐dependent activation process generates Notch intracellular domain (NICD). In the nucleus, NICD forms the transcription activation complex with transcription factor CSL and transcriptional coactivator such as MAML1, initiating the transcription of target genes.