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. 2016 May 26;5(8):2048–2060. doi: 10.1002/cam4.731

Figure 3.

Figure 3

Mutation pattern across diverse SCCs. (A) NOTCH1 mutations identified in tumors of hematopoietic and lymphoid where Notch1 is known as oncogene. Gene alteration data are obtained from COSMIC (B) NOTCH1 mutations identified in CSCC 5. (C‐F) NOTCH1 mutations identified in HNSCC, esophageal SCC, lung SCC, and cervical SCC, respectively. Gene alteration data are obtained from cBioPortal. In (A) and (B), the mutation data are mapped onto Notch1 with cBioPortal tool MutationMapper. The domain organization of Notch1 is labeled under panel (F). Green circles, missense mutations; red circles, nonsense or frame‐shift mutations. NECD, Notch extracellular domain; NICD, Notch intracellular domain; NRR, negative regulatory region; RAM, RBPjκ association module; ANK, ankyrin repeats; PEST, proline/glutamic acid/serine/threonine‐rich motif.