Table 1.
Demographic Characteristics, Clinicopathologic Information, and Univariate Association of Oncologic Risk Factors and 1-Year Mortality
| No. (%) of Patientsa |
||||
|---|---|---|---|---|
| Survival |
||||
| Variable | All (N = 191) | ≥1 Year (n = 138) | <1 Year (n = 53) | P Value |
| Cancer subsite | ||||
| Larynx | 72 (37.7) | 56 (40.6) | 16 (30.2) | <.001b |
| Oral cavity | 72 (37.7) | 50 (36.2) | 22 (41.5) | |
| Oropharynx | 38 (19.9) | 27 (19.6) | 11 (20.8) | |
| Hypopharyx | 9 (4.7) | 5 (3.6) | 4(7.5) | |
| Sex | ||||
| Female | 55 (28.8) | 40 (29.0) | 15 (28.3) | .93 |
| Male | 136 (71.2) | 98 (71.0) | 38 (71.7) | |
| Smoking history | ||||
| Never | 27 (14.1) | 15 (10.9) | 12 (22.6) | .04b |
| Former or current | 158 (82.7) | 118 (85.5) | 40 (75.5) | |
| Alcohol history | ||||
| None | 50 (26.2) | 35 (25.4) | 15 (28.3) | .95 |
| Former or current alcohol history | 122 (63.9) | 86 (62.3) | 36 (67.9) | |
| T stagec | ||||
| 1 | 72 (37.7) | 63 (45.7) | 9 (17.0) | <.001b |
| 2 | 61 (31.9) | 42 (30.4) | 19 (35.8) | |
| 3 | 35 (18.3) | 19 (13.8) | 16 (30.2) | |
| 4 | 19 (9.9) | 10 (7.2) | 9 (17.0) | |
| N stagec | ||||
| N0/1 | 135 (70.7) | 103 (74.6) | 32 (60.4) | .02b |
| N2 or less | 46 (24.1) | 27 (19.6) | 19 (35.8) | |
| Closure | ||||
| Free flap | 30 (15.7) | 17 (12.3) | 13 (24.5) | .05b |
| Primary closure or pedicledflap | 97 (50.8) | 73 (52.9) | 24 (45.3) | |
| Primary radiotherapy | ||||
| Yes | 93 (48.7) | 69 (50.0) | 24 (45.3) | .56 |
| No | 98 (51.3) | 69 (50.0) | 29 (55.7) | |
| Adjuvant therapy | ||||
| None | 103 (53.9) | 80 (58.0) | 23 (43.4) | .009b |
| Radiation | 31 (16.2) | 20 (14.5) | 11 (20.8) | |
| Radiation and chemotherapy | 20 (10.5) | 9 (6.5) | 11 (20.8) | |
| Disease-free interval,mo | ||||
| <6 | 91 (47.6) | 56 (40.6) | 35 (66.0) | .002b |
| ≥6 | 100 (52.4) | 82 (59.4) | 18 (34.0) | |
| Primary extracapsular spread | ||||
| Yes | 17 (8.9) | 5 (3.6) | 12 (22.6) | .89 |
| No | 8 (4.2) | 2 (1.4) | 6 (11.3) | |
| HPV status | ||||
| Positive | 9 (4.7) | 7 (5.1) | 2 (3.8) | .43 |
| Negative | 25 (13.1) | 14 (10.1) | 11 (20.8) | |
| Primary perineural invasion | ||||
| Yes | 26 (13.6) | 14 (10.1) | 12 (22.6) | .20 |
| No | 49 (25.7) | 35 (25.4) | 14 (26.4) | |
| Primary mandible procedure | ||||
| Yes | 20 (10.5) | 12 (8.7) | 8 (15.1) | .29 |
| No | 144 (75.4) | 105 (76.1) | 39 (73.6) | |
| Primary positive margin | ||||
| Yes | 9 (4.7) | 6 (4.3) | 3 (5.7) | >.99 |
| No | 74 (38.7) | 47 (34.1) | 27 (50.9) | |
a
Total No. (%) discrepancies are a result of data points answered as unknown or not applicable.
b
Statistically significant (P < .05).
c
Staging of primary disease at the time of initial diagnosis.