Ascaroside and paratoside-derived metabolites in P. pacificus. Major components of the P. pacificus exo-metabolome derived from assembly of building blocks from carbohydrate, lipid, amino acid (red), and nucleoside (blue) metabolism, as well as TCA cycle-derived succinate (magenta). Also shown is the highly conserved tRNA nucleoside, N6-threonylcarbamoyladenosine (t6A), a putative precursor of paratosides npar#1–3.62