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Interaction of endocannabinoid biosynthesis with peroxisomal β-oxidation. daf-22 mutation abolishes processing of long-chain ascaroside CoA esters, whose conversion into ascaroside ethanolamides is associated with reduced EPEA and anandamide production, likely due to depletion of phosphatidylethanolamine pools. Shown in red are shunt metabolites identified in daf-22 mutant endo-metabolomes via mvaDANS.56
