Table 1.

Proteins involved in cytokinesis.

Generic name	Standard name	Functions	References
Actomyosin-ring components
Actin	Act1	ATPase; structural component involved in actin ring assembly; filament formation	[38], [39], [113]
Myosin-II heavy chain	Myo1	ATPase motor activity; involved in AMR assembly via tail mediated scaffolding	[39], [113]
Essential myosin light chain	Mlc1	Recruitment of Myo1 and Iqg1; stabilization of AMR during constriction	[35], [36], [37], [43], [44], [114] [12]
Regulatory myosin light chain	Mlc2	Binds to myosin-II heavy chain, involved in AMR constriction	[44]
Actomyosin-ring assembly
Septins	Cdc3, Cdc10, Cdc11, Cdc12 Shs1	GTP binding proteins, filament formation; scaffold for AMR assembly	[16], [18], [115], [116]
Septin-interacting protein	Bni5	Myo1 recruitment before cytokinesis; crosslinks septin filaments	[12], [30], [31]
Formins	Bni1, Bnr1	Nucleator of actin filaments	[47], [50], [54]
Rho GTPase	Rho1	Formin activation; actin ring assembly	[47]
Guanine nucleotide exchange factor	Tus1, Rom1, Rom2	Rho1 activation; involved in actin ring assembly	[46]
Tropomyosins	Tpm1, Tpm2	Binds and stabilizes actin filaments	[56]
Profilin	Pfy1	Actin binding protein essential for actin filament nucleation	[48]
IQGAP	Iqg1	Actin filament organization; interacts with Mlc1; AMR stability during constriction	[12], [34], [35], [36], [37], [38]
Actomyosin-ring disassembly
Cofilin	Cof1	Binds both actin monomers and filaments, actin filament severing and depolymerization	[11]
Anaphase promoting complex	APC(Cdh1)	Ubiquitin ligase that promotes the proteasome mediated degradation of AMR remnants after constriction	[42], [67]
SCF ubiquitin ligase	SCF(Grr1)	Ubiquitin ligase that promotes Hof1 degradation; contributes to AMR constriction	[66]
Primary septum formation
Chitin synthase 2	Chs2	Synthesis of the primary septum	[68], [69], [70], [74]
C2-domain protein	Inn1	Chs2 activation; interacts with Hof1 and Cyk3	[77], [79], [80], [81], [82], [87]
Transgluaminase-like protein	Cyk3	Chs2 activation; Rho1 inhibition; interacts with Hof1 and Inn1	[79], [80], [81], [84], [117]
F-BAR protein	Hof1	Primary septum formation, AMR constriction; interacts with Inn1, Cyk3, septins and Sho1	[36], [54], [80], [85], [118] [83]
Secondary septum formation
Rho GTPase	Rho1	GTPase that regulates secondary septum biogenesis by Fks1 activation	[93]
1,3-β glucan synthase	Fks1, Fks2	catalytic subunit of 1,3 beta-D-glucan synthase	[91], [119]
GTPase-mediated polarity switch 1	Gps1 (Aim44)	Rho1 recruitment to the cell division site	[99], [100]
Chitin synthase 3	Chs3	Chitin synthesis	[69], [74], [94]
Cell separation
Chitinase	Cts1	Plays a major role in cell separation after cytokinesis by chitin hydrolysis	[120], [121]
Glucanases	Eng1, Egt2	Plays a major role in cell separation after cytokinesis by glucan hydrolysis	[122], [123]