Table 3.

Multivariable stepwise linear regression analysis with quality of life measured by the CCQ as dependent variable and variables which became significant at p<0.001 in the univariable analyses as independent variables

		Total sample (n=7,810)
	Independent variables	Unadjusted		Adjusted for stage of COPD
Adjusted R2		0.477		0.480
		Unadjusted β (95% CI)	p	Adjusted β (95% CI)	p
Clinical variables	FEV% of predicted value	−0.002 (−0.004, −0.001)	0.001		NS
	Exacerbations during the past 12 months	0.128 (0.105, 0.151)	<0.001	0.125 (0.102, 0.148)	<0.001
Comorbidity	Depression/anxiety	0.202 (0.113, 0.291)	<0.001	0.207 (0.118, 0.295)	<0.001
Patient-reported variables	Exercise capacity, days per week	−0.039 (−0.051, −0.027)	<0.001	−0.039 (−0.051, −0.027)	<0.001
	Functional dyspnoea (MRC)	0.541 (0.512, 0.570)	<0.001	0.530 (0.500, 0.560)	<0.001