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. Author manuscript; available in PMC: 2016 May 30.
Published in final edited form as: Nat Rev Mol Cell Biol. 2015 Nov;16(11):678–689. doi: 10.1038/nrm4074

Figure 3.

Figure 3

Transcription factors and coregulators involved in the regulation of lipogenesis by circadian rhythm.

During the light time, Rev-erbα/β binds to RORE and recruits HDAC3 and NCoR to inhibit lipogenesis in rodents. ROR competitively binds to the same region as Rev-erbα/β at night to activate lipogenesis.