Table 3.
Sr. number | Ingredient (% w/w) | f1 | f2 | f3 | f4 | f5 | f6 | f7 | f8 | f9 |
---|---|---|---|---|---|---|---|---|---|---|
1 | Timolol maleate | 1.40 | 1.418 | 1.470 | 1.438 | 1.449 | 1.464 | 1.478 | 1.484 | 1.492 |
2 | Poloxamer 407 | 46 | 50 | 54 | 46 | 50 | 54 | 46 | 50 | 54 |
3 | HPMC | 0.8 | 0.8 | 0.8 | 1.2 | 1.2 | 1.2 | 1.6 | 1.6 | 1.6 |
4 | Distilled water | q.s. up to 100 mL |
Note: formulation was determined on weight basis not on volume. The % of drug was calculated and added on the weight basis of the polymer so as to ensure that 1 gm of formulation will contain 10 mg of drug.