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. 2016 May 16;2016:2961954. doi: 10.1155/2016/2961954

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Copyright © 2016 Mingyan Hu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Metformin protects against HG + H/R induced cardiac cell injury by inhibiting JNK signaling pathway, which acts downstream of AMPK. H9C2 cells were treated with HG + H/R, metformin (5 mM), metformin + HG + H/R, compound C (1 μM), metformin + HG + H/R + compound C, ANISO (10 μM), and metformin + HG + H/R + ANISO. (a) Expression of P-JNK and T-JNK in each of the treatment conditions was measured by Western blots. (b) Effect of a putative JNK activator ANISO on cell viability was determined using the CCK-8 kit. Data are shown as means ± SD of 3 independent experiments. ^∗ P < 0.05 versus control; ^# P < 0.05 versus HG + H/R; ^& P < 0.05 versus metformin + HG + H/R.