(b).
| Author | Journal | Publication year | PSC (%) | Pancolitis (%) | Immunomodulator use (%) | Biologic use (%) | Observed number of CRCs | Incidence rate (per 100,000 persons) | Standard error | 95% CI lower bound | 95% CI upper bound | Bias rating |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Askling et al. [25] | Gastroenterology | 2001 | 10.3 17.0 4.8 |
143 40 103 |
84.4 43.6 132.9 |
7.1 6.9 13.1 |
70.6 30.1 107.2 |
98.2 57.1 158.6 |
Moderate | |||
|
| ||||||||||||
| Bernstein et al. [24] | Cancer | 2001 | 0.0 0.0 0.0 |
0.0 0.0 0.0 |
60 24 36 |
146.3 112.5 183.1 |
18.9 23.0 30.5 |
109.3 67.5 123.3 |
183.3 157.5 242.9 |
Moderate | ||
|
| ||||||||||||
| Farrell et al. [26] | Gut | 2000 | 26.0 | 30.0 | 3 | 48.0 | 27.7 | −6.3 | 102.3 | Moderate | ||
|
| ||||||||||||
| Fraser et al. [18] | Aliment Pharmacol Ther | 2002 | 30.0 | 0.0 0.0 0.0 |
0.0 0.0 0.0 |
23 4 19 |
41.5 19.5 54.5 |
8.7 9.8 12.5 |
24.5 0.4 30.0 |
58.5 38.6 79.0 |
Moderate | |
|
| ||||||||||||
| Gillen et al. [27] | Gut | 1994 | 37 8 29 |
300.2 344.9 289.9 |
49.4 121.9 53.8 |
203.5 105.9 184.4 |
396.9 583.9 395.4 |
Moderate | ||||
|
| ||||||||||||
| Herrinton et al. [28] | Gastroenterology | 2012 | 82 29 53 |
132.7 101.9 159.0 |
14.7 18.9 21.8 |
104.0 64.8 116.2 |
161.4 139.0 201.8 |
Moderate | ||||
|
| ||||||||||||
| Hou et al. [29] | Inflamm Bowel Dis | 2012 | 183 | 163.0 | 12.0 | 139.4 | 186.6 | Moderate | ||||
|
| ||||||||||||
| Jess et al. [7] | Gastroenterology | 2012 | 338 70 268 |
87.7 53.7 105.0 |
4.8 6.4 6.4 |
78.4 41.1 92.4 |
97.0 66.3 117.6 |
Moderate | ||||
|
| ||||||||||||
| Jess et al. [39] | Aliment Pharmacol Ther | 2004 | 4 | 60.9 | 30.4 | 1.2 | 120.6 | Moderate | ||||
|
| ||||||||||||
| Jussila et al. [10] | Scand J Gastroenterol | 2013 | 189 32 157 |
81.3 61.7 86.9 |
5.9 10.9 6.9 |
69.7 40.3 73.3 |
92.9 83.1 100.5 |
Moderate | ||||
|
| ||||||||||||
| Lakatos et al. [38] | Inflamm Bowel Dis | 2006 | 2.9 | 25.8 | 13 | 151.8 | 42.1 | 69.3 | 234.3 | Moderate | ||
|
| ||||||||||||
| Lakatos et al. [30] | J Crohn's Colitis | 2011 | 1.8 | 5 | 86.8 | 38.8 | 10.7 | 162.9 | Moderate | |||
|
| ||||||||||||
| Lennard-Jones et al. [31] | Gut | 1990 | 22 | 543.5 | 115.9 | 316.4 | 770.6 | Moderate | ||||
|
| ||||||||||||
| Lovasz et al. [32] | J Gastroenterol Liver Dis | 2013 | 0.9 | 34.5 | 47.2 | 7.7 | 6 | 77.3 | 31.6 | 15.4 | 139.2 | Moderate |
|
| ||||||||||||
| Manninen et al. [11] | J Crohn's Colitis | 2013 | 2.5 1.1 3.2 |
43.2 37.7 49.4 |
21 5 16 |
91.7 68.8 102.3 |
20.0 30.8 25.6 |
52.5 8.5 52.2 |
130.9 129.1 152.4 |
Moderate | ||
|
| ||||||||||||
| Mellemkjær et al. [33] | Cancer Causes Control | 2000 | 15 | 65.6 | 16.9 | 32.4 | 98.8 | Moderate | ||||
|
| ||||||||||||
| Mizushima et al. [21] | Digestion | 2010 | 12.4 | 6 | 141.2 | 57.6 | 28.2 | 254.2 | Moderate | |||
|
| ||||||||||||
| Palli et al. [22] | Gastroenterology | 2000 | 12 2 10 |
113.0 73.6 127.0 |
32.6 52.0 40.2 |
49.1 −28.4 48.3 |
176.9 175.6 205.7 |
Moderate | ||||
|
| ||||||||||||
| Pasternak et al. [34] | Am J Epidemiology | 2013 | 0.0 | 0.0 | 380 | 124.6 | 6.4 | 112.1 | 137.1 | Moderate | ||
|
| ||||||||||||
| Selinger et al. [13] | Clin Gastroenterol Hepatol | 2014 | 38.4 37.4 39.1 |
29 5 24 |
216.0 92.3 299.8 |
40.1 41.3 61.2 |
137.4 11.4 179.9 |
294.6 173.2 419.7 |
Moderate | |||
|
| ||||||||||||
| van Schaik et al. [35] | Gut | 2012 | 29.0 | 0.0 | 0.0 | 9 | 185.0 | 61.7 | 64.1 | 305.9 | Moderate | |
|
| ||||||||||||
| Venkataraman et al. [36] | Australian J Gastroenterol Hepatol | 2005 | 44.0 | 5 | 102.0 | 45.6 | 12.6 | 191.4 | Moderate | |||
|
| ||||||||||||
| Wandall et al. [37] | Scand J Gastroenterol | 2000 | 18.0 | 6 | 74.1 | 30.3 | 14.8 | 133.4 | Moderate | |||
|
| ||||||||||||
| Winther et al. [19] | Clin Gastroenterol Hepatol | 2004 | 54.0 | 13 | 58.3 | 16.2 | 26.6 | 90.0 | Moderate | |||
|
| ||||||||||||
| Yano et al. [14] | J Gastroenterol Hepatol | 2013 | 14.7 | 9 | 85.3 | 28.4 | 29.6 | 141.0 | Moderate | |||