(b).
| Author | Journal | Publication year | PSC (%) | Pancolitis (%) | Immunomodulator use (%) | Biologic use (%) | Observed number of leukemia cases | Incidence rate (per 100,000 persons) | Standard error | 95% CI lower bound | 95% CI upper bound | Bias rating |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bernstein et al. [24] | Cancer | 2001 | 0.0 0.0 0.0 |
0.0 0.0 0.0 |
7 3 4 |
17.1 14.1 20.3 |
6.5 8.1 10.2 |
4.4 −1.9 0.4 |
29.8 30.1 40.2 |
Moderate | ||
|
| ||||||||||||
| Fraser et al. [18] | Aliment Pharmacol Ther | 2002 | 30.0 | 0.0 | 0.0 | 1 | 1.81 | 1.8 | −1.7 | 5.4 | Moderate | |
|
| ||||||||||||
| Jess et al. [8] | Am J Gastroenterol | 2013 | 26.7 41.0 19.0 |
27.2 45.0 18.0 |
6 1 5 |
17.7 8.9 22.1 |
7.2 8.9 9.9 |
3.5 −8.5 2.7 |
31.9 26.3 41.5 |
Moderate | ||
|
| ||||||||||||
| Jess et al. [39] | Aliment Pharmacol Ther | 2004 | 1 | 15.2 | 15.2 | −14.6 | 45.1 | Moderate | ||||
|
| ||||||||||||
| Lopez et al. [23] | Clin Gastroenterol Hepatol | 2014 | 0.0 | 0.0 | 0.5 | 2.13 | 3.0 | −3.8 | 8.0 | Moderate | ||
|
| ||||||||||||
| Mellemkjær et al. [33] | Cancer Causes Control | 2000 | 3 | 13.1 | 7.6 | −1.7 | 27.9 | Moderate | ||||
|
| ||||||||||||
| Mizushima et al. [21] | Digestion | 2010 | 12.4 | 0 | 0.0 | 0.0 | 3.7 | Moderate | ||||
|
| ||||||||||||
| Palli et al. [22] | Gastroenterology | 2000 | 2 0 2 |
19.0 0.0 25.4 |
13.4 18.0 |
−7.3 0.0 −9.8 |
45.3 3.7 60.6 |
Moderate | ||||
|
| ||||||||||||
| Winther et al. [19] | Clin Gastroenterol Hepatol | 2004 | 54.0 | 4 | 8.97 | 4.5 | 0.2 | 17.8 | Moderate | |||
|
| ||||||||||||
| Yano et al. [14] | J Gastroenterol Hepatol | 2013 | 14.7 | 3 | 28.4 | 16.4 | −3.7 | 60.5 | Moderate | |||
∗Did not report separate incidence measures for CD and UC.