(a).
| Author | Journal | Publication year | Study design | Study population | Region of origin | Number of sites | Study duration (yrs) | Person-years | Number of patients | Diagnosis | Mean age (yrs) | Female (%) | Mean disease duration (yrs) | Surgery (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Abbas et al. [40] | Am J Gastroenterol | 2012 | Cohort | National registry | United States | Countrywide | 11.0 | 352,429 | 32,039 | UC | 60.0 | 7.0 | ||
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| Beaugerie et al. [41] | Lancet | 2009 | Cohort | National registry | Europe (Western) | Countrywide | 3.0 | 22,706 10,899 11,807 |
10,810 5,153 5,657 |
IBD CD UC |
53.0 | |||
|
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| Bernstein et al. [24] | Cancer | 2001 | Case-control | Administrative claims | Canada | Regionwide | 14.0 | 41,005 21,340 19,665 |
5,529 2,857 2,672 |
IBD CD UC |
39.0 36.3 41.7 |
54.5 59.0 50.0 |
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| Chiorean et al. [42] | Dig Dis Sci | 2011 | Case-control | Referral center | United States | 1 | 8.4 | 30,121 19,127 10,994 |
3,585 2,277 1,308 |
IBD CD UC |
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| Farrell et al. [26] | Gut | 2000 | Cohort | Referral center | Europe (Western) | 1 | 9.0 | 6,256 | 782 | IBD∗ | 44.1 | 52.0 | 10.0 | |
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| Fraser et al. [18] | Aliment Pharmacol Ther | 2002 | Cohort | Referral center | Europe (Western) | Countrywide | 35.0 | 55,388 20,494 34,894 |
1,578 584 994 |
IBD CD UC |
35.0 | 53.0 | ||
|
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| Herrinton et al. [43] | Am J Gastroenterol | 2011 | Cohort | Administrative claims | United States | Regionwide | 13.0 | 67,867 | 16,023 | IBD∗ | 53.0 | |||
|
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| Jess et al. [8] | Am J Gastroenterol | 2013 | Cohort | Regional registry | Europe (Western) | 1 | 32.0 | 33,843 11,261 22,582 |
2,211 774 1,437 |
IBD CD UC |
53.0 57.0 49.0 |
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|
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| Jess et al. [39] | Aliment Pharmacol Ther | 2004 | Cohort | Regional registry | Europe (Western) | Regionwide | 35.0 | 6,569 | 374 | CD | 58.0 | |||
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| Jussila et al. [10] | Scand J Gastroenterol | 2013 | Cohort | National registry | Europe (Western) | Countrywide | 23.0 | 232,536 51,876 180,660 |
20,970 4,983 15,987 |
IBD CD UC |
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|
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| Khan et al. [44] | Gastroenterology | 2013 | Cohort | National registry | United States | Countrywide | 10.0 | 199,046 | 36,891 | UC | 60.0 | 7.0 | ||
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| Lakatos et al. [45] | J Crohn's Colitis | 2012 | Cohort | Provincial registry | Europe (Eastern) | 7 | 31.0 | 19,293 7,093 12,830 |
1,420 506 914 |
IBD CD UC |
32.5 28.5 36.5 |
48.8 50.0 47.6 |
22.8 41.3 4.2 |
|
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| Lewis et al. [46] | Gastroenterology | 2001 | Cohort | National registry | Europe (Western) | Countrywide | 9.0 | 64,239 24,221 40,018 |
16,996 6,605 10,391 |
IBD CD UC |
47.3 44.3 50.3 |
54.0 58.0 50.0 |
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| Loftus Jr. et al. [47] | Am J Gastroenterol | 2000 | Cohort | Regional registry | United States | 2 | 53.0 | 6,662 3,150 3,512 |
454 216 238 |
IBD CD UC |
24.0 | 14.9 | ||
|
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| Mellemkjær et al. [33] | Cancer Causes Control | 2000 | Cohort | National registry | Europe (Western) | Countrywide | 16.0 | 22,875 | 2,645 | CD | 50.0 | |||
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| Mizushima et al. [21] | Digestion | 2010 | Cohort | Referral center | Asia | 1 | 20.0 | 4,248 | 294 | CD | 39.0 | 30.6 | ||
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| Palli et al. [22] | Gastroenterology | 2000 | Cohort | Regional registry | Europe (Western) | 1 | 19.0 | 10,592 2,716 7,877 |
920 231 689 |
IBD CD UC |
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| Pasternak et al. [34] | Am J Epidemiology | 2013 | Cohort | National registry | Europe (Western) | Countrywide | 11.0 | 304,992 | 38,772 | IBD∗ | 47.0 | 55.0 | 4.0 | |
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| Van Domselaar et al. [48] | J Gastroenterol Hepatol | 2010 | Cohort | Referral center | Europe (Western) | 1 | 8,563 | 911 | IBD∗ | 53.0 | 28.6 | 4.8 | ||
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| Winther et al. [19] | Clin Gastroenterol Hepatol | 2004 | Cohort | Regional registry | Europe (Western) | Regionwide | 35.0 | 22,290 | 1,160 | UC | 53.4 | |||
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| Yano et al. [14] | J Gastroenterol Hepatol | 2013 | Cohort | Referral center | Asia | 1 | 25.0 | 10,552 | 770 | CD | 25.1 | 31.3 | 13.1 | |