(b).
| Author | Journal | Publication year | PSC (%) | Pancolitis (%) | Immunomodulator use (%) | Biologic use (%) | Observed number of lymphomas | Incidence rate (per 100,000 persons) | Standard error | 95% CI lower bound | 95% CI upper bound | Bias rating |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Abbas et al. [40] | Am J Gastroenterol | 2012 | 0.0 | 0.0 | 282 | 80.0 | 4.8 | 70.7 | 89.3 | Moderate | ||
|
| ||||||||||||
| Beaugerie et al. [41] | Lancet | 2009 | 29.6 13.0 16.0 |
0.0 0.0 0.0 |
0.0 0.0 0.0 |
6 3 3 |
26.4 27.5 25.4 |
10.8 15.9 14.7 |
5.3 −3.6 −3.3 |
47.5 58.6 54.1 |
Moderate | |
|
| ||||||||||||
| Bernstein et al. [24] | Cancer | 2001 | 0.0 0.0 0.0 |
0.0 0.0 0.0 |
16 9 7 |
39.0 42.2 35.6 |
9.8 14.1 13.5 |
19.9 14.6 9.2 |
58.1 69.8 62.0 |
Moderate | ||
|
| ||||||||||||
| Chiorean et al. [42] | Dig Dis Sci | 2011 | 8 5 3 |
26.6 26.1 27.3 |
9.4 11.7 15.8 |
8.2 3.2 −3.6 |
45.0 49.0 58.2 |
Moderate | ||||
|
| ||||||||||||
| Farrell et al. [26] | Gut | 2000 | 26.0 | 30.0 | 4 | 64.0 | 32.0 | 1.3 | 126.7 | Moderate | ||
|
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| Fraser et al. [18] | Aliment Pharmacol Ther | 2002 | 30.0 | 0.0 0.0 0.0 |
0.0 0.0 0.0 |
5 1 4 |
9.0 4.87 11.5 |
4.0 4.9 5.8 |
1.1 −4.7 0.2 |
16.9 14.4 22.8 |
Moderate | |
|
| ||||||||||||
| Herrinton et al. [43] | Am J Gastroenterol | 2011 | 0.0 | 0.0 | 33 | 48.6 | 8.5 | 32.0 | 65.2 | Moderate | ||
|
| ||||||||||||
| Jess et al. [8] | Am J Gastroenterol | 2013 | 26.7 41.0 19.0 |
27.2 45.0 18.0 |
15 7 8 |
44.3 62.2 35.4 |
11.4 23.5 12.5 |
21.9 16.1 10.9 |
66.7 108.3 59.9 |
Moderate | ||
|
| ||||||||||||
| Jess et al. [39] | Aliment Pharmacol Ther | 2004 | 0 | 0.0 | 0.0 | 3.7 | Moderate | |||||
|
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| Jussila et al. [10] | Scand J Gastroenterol | 2013 | 72 14 58 |
31.0 27.0 32.1 |
3.7 7.2 4.2 |
23.8 12.9 23.8 |
38.2 41.1 40.4 |
Moderate | ||||
|
| ||||||||||||
| Khan et al. [44] | Gastroenterology | 2013 | 0.0 | 0.0 | 119 | 60.0 | 5.5 | 49.2 | 70.8 | Moderate | ||
|
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| Lakatos et al. [45] | J Crohn's Colitis | 2012 | 2.3 1.8 2.7 |
30.2 35.9 24.4 |
0.0 0.0 0.0 |
0.0 0.0 0.0 |
3 1 2 |
15.5 14.1 15.6 |
8.9 14.1 11.0 |
−2.0 −13.5 −6.0 |
33.0 41.7 37.2 |
Moderate |
|
| ||||||||||||
| Lewis et al. [46] | Gastroenterology | 2001 | 9.5 13.0 6.0 |
18 7 11 |
28.0 28.9 27.5 |
6.6 10.9 8.3 |
15.1 7.5 11.2 |
40.9 50.3 43.8 |
Moderate | |||
|
| ||||||||||||
| Loftus Jr. et al. [47] | Am J Gastroenterol | 2000 | 1 1 0 |
15.0 32.0 0.0 |
15.0 32.0 |
−14.4 −30.7 0.0 |
44.4 94.7 3.7 |
Moderate | ||||
|
| ||||||||||||
| Mellemkjær et al. [33] | Cancer Causes Control | 2000 | 4 | 17.5 | 8.8 | 0.4 | 34.7 | Moderate | ||||
|
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| Mizushima et al. [21] | Digestion | 2010 | 12.4 | 0 | 0.0 | 0.0 | 3.7 | Moderate | ||||
|
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| Palli et al. [22] | Gastroenterology | 2000 | 7 1 6 |
66.0 36.8 76.2 |
24.9 36.8 31.1 |
17.1 −35.3 15.2 |
114.9 108.9 137.2 |
Moderate | ||||
|
| ||||||||||||
| Pasternak et al. [34] | Am J Epidemiology | 2013 | 0.0 | 0.0 | 46 | 15.1 | 2.2 | 10.7 | 19.5 | Moderate | ||
|
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| Van Domselaar et al. [48] | J Gastroenterol Hepatol | 2010 | 7 | 81.7 | 30.9 | 21.2 | 142.2 | Moderate | ||||
|
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| Winther et al. [19] | Clin Gastroenterol Hepatol | 2004 | 54.0 | 2 | 17.9 | 12.7 | −6.9 | 42.8 | Moderate | |||
|
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| Yano et al. [14] | J Gastroenterol Hepatol | 2013 | 14.7 | 0 | 0.0 | 0.0 | 3.7 | Moderate | ||||
∗Did not report separate incidence estimates for CD and UC.