Table 4.
Association (odds ratios and 95% CI) between type 2 diabetes and impaired kidney function, stratified by key risk factors.
| eGFR | Cases (<60 ml/min/1.73 m2) | Controls (≥60 ml/min/1.73 m2) | p for interaction |
|---|---|---|---|
| Age | |||
| <60 years | 1.57 (1.15–2.13) | Ref (1.00) | 0.73 |
| ≥60 years | 2.23 (1.47–3.36) | Ref (1.00) | |
| Sex | 0.88 | ||
| Male | 1.36 (0.92–2.00) | Ref (1.00) | |
| Female | 1.68 (1.23–2.30) | Ref (1.00) | |
| Body mass index | 0.28 | ||
| Normal | 1.51 (1.02–2.22) | Ref (1.00) | |
| Overweight | 1.23 (0.82–1.85) | Ref (1.00) | |
| Obese | 1.93 (1.14–3.27) | Ref (1.00) | |
| Hypertension | 0.17 | ||
| No | 1.23 (0.81–1.86) | Ref (1.00) | |
| Yes | 1.71 (1.26–2.32) | Ref (1.00) | |
| HDLc | < 0.01 | ||
| <1.04 mmol/l | 1.83 (1.22–2.73) | Ref (1.00) | |
| ≥1.04 mmol/l | 1.40 (1.04–1.88) | Ref (1.00) | |
| LDLc | 0.50 | ||
| <4.14 mmol/l | 1.87 (1.35–2.61) | Ref (1.00) | |
| ≥4.14 mmol/l | 1.27 (0.89–1.80) | Ref (1.00) | |
| Triglycerides | 0.54 | ||
| <2.26 mmol/l | 1.52 (1.17–1.96) | Ref (1.00) | |
| ≥2.26 mmol/l | 2.69 (1.24–5.87) | Ref (1.00) |
GFR was estimated using the MDRD equation.
Logistic regression models were used to estimate the odds ratios and 95% confidence intervals.
Each model was adjusted for age, sex, body mass index, hypertension, HDL, LDL, and triglyceride.