Figure 4. TTL-315 blocks the growth of MMTV-neu mammary carcinoma and cooperates with cisplatin to promote regression of established tumors.

Tumor volumes comparing control and experimental cohorts relative to the starting day of treatment is shown on a logarithmic scale on the Y-axis. Each dot represents a subject on trial (n). Horizontal bars in each dataset shows the mean of the data. Statistical significance was analyzed by ANOVA. MMTV-neu mice with spontaneously arising palpable mammary tumors (500-1000 mm³) were recruited longitudinally to a trial in which TTL-315 (100 mg/kg), cisplatin (1 mg/kg) or vehicle only (0.1 ml volume) was administered by i.p. injection on days 1, 3, 5 of a two-week response trial.