Table 1. Differential gene expression upon GDF-15 gene silencing in glioma cells.
Symbol | Name | LNT-229 | LN-308 |
---|---|---|---|
SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 3.00 | 2.85 |
GDF15 | growth and differentiation factor 15 | 2.58 | 5.15 |
RGS4 | regulator of G-protein signaling 4 | 2.54 | 1.54 |
ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 2.16 | 1.42 |
CAPN3 | calpain 3, (p94) | 2.02 | 1.21 |
MICAL2 | microtubule associated monoxygenase, calponin and LIM domain containing 2 | 1.72 | 1.29 |
PLAT | plasminogen activator, tissue | 1.70 | 1.40 |
TNC | tenascin C | 1.65 | 1.33 |
PLAUR | plasminogen activator, urokinase receptor | 1.61 | 1.33 |
L1CAM | L1 cell adhesion molecule | 1.58 | 1.22 |
PTMA | prothymosin, alpha | 1.66 | 1.55 |
JUN | jun proto-oncogene | 1.48 | 1.41 |
SLC2A10 | solute carrier family 2 (facilitated glucose transporter), member 10 | 1.45 | 1.47 |
CD59 | CD59 molecule, complement regulatory protein | 1.45 | 1.43 |
ACADVL | acyl-CoA dehydrogenase, very long chain | 1.43 | 1.37 |
SLC25A46 | solute carrier family 25, member 46 | 1.41 | 1.24 |
DDR1 | discoidin domain receptor tyrosine kinase 1 | 1.40 | 1.21 |
TPST1 | tyrosylprotein sulfotransferase 1 | 1.39 | 1.26 |
PON2 | paraoxonase 2 | 1.36 | 1.29 |
LEPREL2 | leprecan-like 2 | 1.36 | 1.41 |
GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | 1.34 | 1.42 |
KYNU | kynureninase (L-kynurenine hydrolase) | 1.33 | 1.06 |
HIPK2 | homeodomain interacting protein kinase 2 | 1.33 | 1.14 |
PLIN3 | perilipin 3 | 1.31 | 1.15 |
TMPO | thymopoietin | 1.31 | 1.23 |
UBE4B | ubiquitination factor E4B (UFD2 homolog, yeast) | 1.31 | 1.08 |
ANXA1 | annexin A1 | 1.30 | 1.11 |
MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 1.29 | 1.05 |
The most deregulated genes for both cell lines are shown. Bold values imply up-regulation, with fold change values expressed as x=(GDF-15 siRNA/scrambled siRNA). Grey values represents down-regulation and fold change values are expressed as x=(scrambled siRNA/GDF-15 siRNA). Significant genes were included for a p value cut-off of 0.01 for non-paired T test