Table 1. Differential gene expression upon GDF-15 gene silencing in glioma cells.

Symbol	Name	LNT-229	LN-308
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	3.00	2.85
GDF15	growth and differentiation factor 15	2.58	5.15
RGS4	regulator of G-protein signaling 4	2.54	1.54
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	2.16	1.42
CAPN3	calpain 3, (p94)	2.02	1.21
MICAL2	microtubule associated monoxygenase, calponin and LIM domain containing 2	1.72	1.29
PLAT	plasminogen activator, tissue	1.70	1.40
TNC	tenascin C	1.65	1.33
PLAUR	plasminogen activator, urokinase receptor	1.61	1.33
L1CAM	L1 cell adhesion molecule	1.58	1.22
PTMA	prothymosin, alpha	1.66	1.55
JUN	jun proto-oncogene	1.48	1.41
SLC2A10	solute carrier family 2 (facilitated glucose transporter), member 10	1.45	1.47
CD59	CD59 molecule, complement regulatory protein	1.45	1.43
ACADVL	acyl-CoA dehydrogenase, very long chain	1.43	1.37
SLC25A46	solute carrier family 25, member 46	1.41	1.24
DDR1	discoidin domain receptor tyrosine kinase 1	1.40	1.21
TPST1	tyrosylprotein sulfotransferase 1	1.39	1.26
PON2	paraoxonase 2	1.36	1.29
LEPREL2	leprecan-like 2	1.36	1.41
GNA11	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	1.34	1.42
KYNU	kynureninase (L-kynurenine hydrolase)	1.33	1.06
HIPK2	homeodomain interacting protein kinase 2	1.33	1.14
PLIN3	perilipin 3	1.31	1.15
TMPO	thymopoietin	1.31	1.23
UBE4B	ubiquitination factor E4B (UFD2 homolog, yeast)	1.31	1.08
ANXA1	annexin A1	1.30	1.11
MLLT11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11	1.29	1.05

The most deregulated genes for both cell lines are shown. Bold values imply up-regulation, with fold change values expressed as x=(GDF-15 siRNA/scrambled siRNA). Grey values represents down-regulation and fold change values are expressed as x=(scrambled siRNA/GDF-15 siRNA). Significant genes were included for a p value cut-off of 0.01 for non-paired T test