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. 2016 Jan 14;7(7):7993–8005. doi: 10.18632/oncotarget.6919

Figure 4. Tumors appearance changes with passage.

Figure 4

Representative images of hematoxilin and eosin stain of tissue samples of PDX-SCC-M0 in A and B, and UM-PDX-HACC-5 in C and D are shown at different passages. Pictures were taken at x400 magnification in A, C, and D and at x200 magnification in B. Scale bars represent 50 μm in all images. The symbol 0* represents the original patient tumor sample prior to implantation in mouse. A. We observed that there appeared to be increasing band of nuclear pleomorphism associated with increased passage number (between arrows). B. Decreasing inflammatory infiltrate over passages was also identified. C. The adenoid cystic carcinoma growth pattern changed dramatically over passages. D. The mitotic count also increased appreciably (arrows mark mitotic figures).