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. 2016 Jan 14;7(7):7993–8005. doi: 10.18632/oncotarget.6919

Figure 5. Squamous cell carcinoma PDX models decrease inflammation and stromal tissue with passage.

Figure 5

Blinded samples from PDX-SCC-M0 were provided to oral pathologists for scoring across passages. N = 57 tissue sample slides. The symbol 0* represents the original patient tumor sample prior to implantation in mouse. A. Inflammatory infiltration score B. invasiveness pattern score C. keratinization score and D. nuclear pleomorphism score were compared to passage number. Lower scores represent histopathologically more aggressive characteristics. Correlations were assessed by Spearman's Rank-Correlation. E. Inflammatory cell count and F. proportion of tumor comprised of stromal tissue were compared to passage number. Correlations were assessed by Pearson Correlation Coefficient.