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. 2016 Jan 12;7(7):8006–8018. doi: 10.18632/oncotarget.6895

Figure 2. The homologous recombination of the OR4F3 5′UTR and HBV P gene.

Figure 2

A. A schematic alignment of OR4F3 and HBV is presented. The complementary sites between the OR4F3 gene and the HBV genome P gene are indicated by red frames. B. Compared with the control (Con), the agarose gel electrophoresis results show the OR4F3 and HBV chimeric fusion genes in the HBV-HCC samples. Sequencing results show one complementary site and a short HBV P gene sequence. The M lanes contain the DNA size markers (DL2000). The Con lane is healthy control, and lanes 1 and 2 are the HBV-HCC samples. UTR (untranslated region). C. The OR4F3 and HBV P gene chimeric fusion genes in the leukocyte genome are shown. Agarose gel electrophoresis showing the PCR amplification products for the healthy control (Con), non-HBV-HCC (N), non-active HBV-HCC (NA), active HBV-HCC (A), and antiviral therapy (AT) samples as well as marker (M). The chimeric fusion DNA fragments of P gene and OR4F3 were observed in the sorted NK cells of HBV- samples and B cells of samples from patient receiving antiviral therapy. T-lymphocyte cells (T cells); B-lymphocyte cells (B cells); Natural killer cells (NK cells).