Skip to main content
. 2016 Jan 23;7(7):8119–8130. doi: 10.18632/oncotarget.6992

Figure 6. H3K27 hypomethylating agents induce varying degrees of HOX gene cluster expression.

Figure 6

(A) DZNep and EPZ005687 increased cell apoptosis in SKM-1 and MDS-L cells in a dose-dependent manner. (B) DZNep and EPZ005687 reduced EZH2 expression in SKM-1 and MDS-L cells. (C) and (D) Co-treatment with low concentrations (0.5 μM) of DZNep and EPZ005687 increased HOX gene cluster expression in SKM-1 and MDS-L cells. (E) Western blot analysis showed that both DZNep and EPZ005687 reduced EZH2 expression and H3K27me3 levels. Statistical significance relative to the control group is indicated: *p < 0.05; **p < 0.01; ***p < 0.001 (two-tailed, Student's t-test). Error bars show SEM.