Figure 4. Anti-angiogenic properties of the identified HIF-1 inhibitors.
(A) Fluorescence images of GFP-expressing aortic endothelial cells in the presence of various concentrations of mycophenolate mofetil. (B) Tube formation and viability of co-cultures of human aortic endothelial cells and human mesenchymal stem cells after a 3-day exposure of PI-103, trametinib, mycophenolate mofetil, and niclosamide under normoxic condition. Assay data are expressed as mean ± SD from three measurements.