Table 2. Characteristics of the study participants and comparison of patients with and without a pathogenic mutation.
| Variants | Without | With | P value |
|---|---|---|---|
| Patient number | 103 | 30 | |
| Median (range) | 44 (25–75) | 41 (29–60) | 0.309 |
| ≤ 35 years (patient no.) | 30 | 11 | |
| > 35–50 years (patient no.) | 45 | 11 | |
| > 50 years (patient no.) | 28 | 8 | |
| Personal history | |||
| Single/Metachronous breast cancer | 94/9 | 26/4 | 0.456 |
| Ovarian cancer | 4 | 1 | |
| Other cancer | 4 | 1 | |
| Molecular type | 0.025 | ||
| HR(+)Her2(−) | 68 | 16 | |
| HR(+)Her2(+) | 16 | 4 | |
| HR(−)Her2(+) | 7 | 0 | |
| TNBC | 12 | 10 | |
| Family cancer history | |||
| Breast cancer | 74 | 23 | 0.650 |
| Ovarian cancer | 10 | 5 | 0.327 |
| Prostate cancer | 3 | 4 | 0.024 |
| Male breast cancer | 0 | 2 | 0.008 |
| Other cancers | 31 | 11 | 0.510 |
| Criteria of enrollment | 0.304 | ||
| (1) | 23 | 6 | |
| (2) | 45 | 10 | |
| (3) | 34 | 15 | |
(1)
Early-onset breast cancer (age ≤ 35 years) or bilateral breast cancer (without family hsitory)
(2)
Breast cancer onset age ≤ 50 years and at least one first or second-degree relative with breast cancer or ovarian cancer
(3)
Breast cancer onset after the age of 50 years, but with two relatives with breast cancer or one with ovarian cancer.