Figure 5. Map of SETDB1 mutations identified in MPMs.

Nine SETDB1 somatic mutations identified in this study and reported previously were mapped in domains of SETDB1. Four of five truncating mutations were located at the N-terminal (5′) regions before Tudor (Tud) domains. All three missense and one deletion mutation were found in the SET domain. Tud: Tudor; MBD: methyl-CpG-binding domain; pS: pre-SET; PS: post-SET [30–31].