. 2016 May 30;3:24. doi: 10.3389/fmed.2016.00024

Table 1.

Key gene polymorphisms and their significance in intestinal fibrosis in CD.

Gene	Polymorphism	Association	Studied population	Sample size^e	Reference
NOD2	rs2066844, R702W	Discussed separately in Table 2
	rs2066845, G908R
	rs2066847, Leu1007fsinC
ATG16L1	rs2241880, T300A	Ileal disease location	Australian	669–154	Fowler et al. (58)
ATG16L1	rs2241880, T300A	Fibrostenotic disease^a	Australian	669–154	Fowler et al. (58)
IL-23R	rs1004819	Ileal disease location^b	German	833	Glas et al. (65)
IL-23R	rs1004819	Fibrostenotic disease^a^,^b	German	833	Glas et al. (65)
CX3CR1	rs3732379, V249I/rs3732378, T280M	Ileocolonic disease location	German	206	Brand et al. (74)
	rs3732379, V249I/rs3732378, T280M	Fibrostenotic disease^a	German	206	Brand et al. (74)
	rs3732379, V249I	Fibrostenotic disease^a	Caucasian	239	Sabate et al. (52)
TGF-β	rs1800471, R25P	Fibrostenotic disease^c	Australian	235–112	Hume et al. (79)
MMP-3	−1613 5T6T	Colonic disease location	Dutch	134	Meijer et al. (88)
MMP-3	−1613 5T6T	Fibrostenotic disease^a	Dutch	134	Meijer et al. (88)
MAGI1	rs11924265	Fibrostenotic disease^d	Spanish	1090–1296	Alonso et al. (96)
JAK2	rs10758669	Ileal disease location	Caucasian	1528	Cleynen et al. (50)
JAK2	rs10758669	Fibrostenotic disease^d	Caucasian	1528	Cleynen et al. (50)
FUT2	rs601338	Fibrostenotic disease^d	Belgian	647	Forni et al. (99)
IL12B	rs1363670	Fibrostenotic disease^d	Belgian	875	Henckaerts et al. (103)

If a significant association between the given variant and disease location is found in the reference, this is mentioned in the table.

^aNot corrected for disease location.

^bNot significant after Bonferroni correction.

^cNo longer significant after multivariate analysis taking into account disease location.

^dCorrected for disease location.

^eNumber of included CD patients in primary cohort − number of included CD patients in replication cohort (if applicable).