Table 2.

Human GO term enrichment. Human orthologues of zebrafish genes up-regulated in unc45b−/− at 72 hpf were used to query GO terms and assess pathway enrichment with a Fisher׳s exact-test.

GO ID	GO Name	Fisher p-value	Genes
GO:0001666	Response to hypoxia	1.47E−09	PPARA,RAF1,PLAT,SDC2,CITED2,MTHFR,CXCR4,PGF,ALKBH5,TGFB1,VEGFA,ABAT,PDLIM1,EPO,TGFBR3,ARNT,ALAS2,SMAD9,PDGFB, ANGPT2,LIMD1,MECP2,STAT5B,PLOD1
GO:0032355	Response to estradiol	7.56E−09	PTGS2,KCNJ11,TGFB1,RNF14,ASS1,TACR1,WNT7A,ANXA1,CASP9,NCOA1,PDGFB,IGFBP2, SLC25A36,GHR,STAT5B
GO:0030018	Z disc	2.42E−07	MYH6,XIRP2,PDLIM5,MYPN,SLC4A1,SYNPO2,JPH2,BIN1,SLC8A1,PGM5,MYL9,SYNPO2L,OBSL1
GO:0007596	Blood coagulation	4.44E−07	SLC7A8,PLEK,RAF1,PSAP,PLAT,SERPINE1,ITGA4,SOS1,PLA2G4A,LYN,FLNA,ANO6,TGFB1, PDE11A,GATA1,VEGFA,PDE10A,PDE2A,PIK3R5,L1CAM,ZFPM1, PRKG1,ITGB3,LRRC16A,MERTK,SLC8A1,PDGFB,ANGPT2,DOCK1,HBE1,GATA4,SERPINB2, PRKACB,SLC16A1,SLC3A2
GO:0030334	Regulation of cell migration	6.68E−07	ROBO4,NOTCH1,CXCR4,TGFB1,JAG1,LAMA3,UNC5C,LAMA2,HACE1,ITGB3,PTPN23,LAMA1
GO:0002040	Sprouting angiogenesis	7.57E−07	NOTCH1,ESM1,PGF,NRARP,VEGFA,JMJD6,GPR124
GO:0007507	Heart development	7.91E−07	TBX5,PPARA,PPARG,RAF1,CITED2,RBM20,ITGA4,SALL4,ACVR2B,NOTCH1,ZFP36L1, SOX9,JMJD6,TGFBR1,PAX3,WT1,GLI2,ZFPM1,PDGFB,GATA4,RBPJ,SOX18
GO:0009986	Cell surface	8.33E−07	PLAT,ITGA4,NOTCH1,CXCR4,GPRC5B,LRP4,ANO6,TIMP2,TGFB1,CSF1R,VEGFA,HBEGF,EPHA2,CLMP, TACR1,WNT7A,L1CAM,ANXA1,PTGFRN,TFRC,GPR124,EPO,ITGB3,TGFBR3,KCNH2,GREM1,SDC4, CNTNAP2,LRRC8A,MST1R,PDGFB,ANXA2,SPTB,GHR,FGFR3,SLC3A2
GO:0001837	Epithelial to mesenchymal transition	8.57E−07	SNAI1,NOTCH1,FLNA,TGFB1,SOX9,HMGA2,TGFBR1,TGFBR3,RBPJ
GO:0007220	Notch receptor processing	9.90E−07	NOTCH1,JAG1,NOTCH3,UBB,DLL4,DLL1