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Catalytic M domain structure. (A) Structure of the M domain of catrocollastatin/VAP2B in complex with GM6001 (2DW0). The upper and lower subdomains are colored in gold and magenta respectively. (B) Close up view of the catalytic site. (C) Close up view of the Ca2+-binding site of catrocollastatin/VAP2B (shown in orange) overlaid on the corresponding region of VAP1 (shown in gray). Residues in catrocollastatin/VAP2B and VAP1 are indicated in black and cyan, respectively.
