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. 2016 May 17;8(5):155. doi: 10.3390/toxins8050155

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© 2016 by the author; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Arm structure. (A) The D_s, D_a, and C_w subdomains of catrocollastatin/VAP2B (2DW0) are shown in cyan, pink, and gray, respectively. (B) The D domain of K-like proteinase (3K7N) with two different views of the D_s subdomain (in dotted line boxes). Close up views of the Ca²⁺-binding sites, II (C) and III (D) in catrocollastatin/VAP2B. (E) Structure of an RGD-containing disintegrin, trimestatin (1J2L). Suggested integrin-binding residues are indicated. (F) Amino acid sequence alignment of catrocollastatin/VAP2B (PDB: 2DW0_A), VAP1 (PDB: 2ERO_A), RVV-X (PDB: 2E3X_A), human ADAM28 (Genbank ID (GI): 98985828), human ADAM10 (GI: 29337031), human ADAM17 (GI: 14423632), K-like (PDB: 3K7Y_A) and trimestatin (1J2L_A) generated using Clustal X2 (http://www.clustal.org/clustal2/). Disulfide bonds and the boundaries of the subdomains are schematically indicated. Ca²⁺-binding sites II and III are boxed in red.