Figure 7.

Structure of VAP1, representative of P-IIIc SVMPs. (A) Crystal structure of VAP1 (2ERO) viewed from the dimer axis. (B) Dimer interface viewed from a direction nearly perpendicular to the dimer axis. The molecular surface of the cyan molecule in the back is colored according to electrochemical potential (red to blue). (C) Close up view of the dimer interface. The residues involved in the inter-chain interactions are indicated with blue and red letters for cyan and yellow molecules. (D) Close up view of the catalytic cleft of the VAP1 (shown with the molecular surface)/GM6001 (shown in yellow) complex structure.