Table 4. Full Pharmacokinetic Parameters of Compound 27 Compared to Compound 2 at a Dose of 10 mg/kg.

compd (route)	AUC0–lasta (μg·min/mL)	AUC0–∞b (μg·min/mL)	Cmaxc (μg/mL)	Tmaxd (h)	CLe (mL min–1 kg–1)	Vdf (L/kg)	t1/2g	Fh (%)
27 (iv)	1540	1570			6.4	3.58	t1/2α = 3.6 min
							t1/2β = 6.5 h
27 (po)	552	582	2.7	0.5			t1/2α = 2.4 h	37
							t1/2β = 6.6 h
2 (iv)i	1180	1460			6.9	0.30	t1/2α = 35.2 min
							t1/2β ≥ 20 h
2 (po)i	408	738	1.3	1			t1/2α = 1.9 h	50
							t1/2β > 20 h

^aAUC_0–last = area under the curve from 0 min to the last quantifiable time point.

^bAUC_0–-∞ = area under the curve from 0 min extrapolated to infinity.

^cC_max = maximum concentration.

^dT_max = time at which maximum concentration is achieved.

^eCL = clearance.

^fV_d = volume of distribution.

^gt_1/2α = half-life of distribution. t_1/2β = half-life of elimination.

^hF = oral bioavailbility.

ⁱData for compound 2 reproduced from Bouley et al. for comparison.