. 2016 Apr 26;59(10):4697–4710. doi: 10.1021/acs.jmedchem.6b00065

Table 1. IC₅₀ Values (in nM) Calculated for PP1, 7i–k, 8d, 9d, 11a, and Dasatinib in a Selection of Recombinant Kinases.

kinase \ hit	PP1	7i	7j	7k	8d	9d	11a	dasatinib
ABL	147	6323	7525	7249	1207	116	479	<0.5
FYN^a	27	311	913	1964	1226	38	2.1	<0.5
KIT	1318	>10⁴	>10⁴	>10⁴	>10⁴	>10⁴	>10⁴	39
mTOR	9318	>10⁴	>10⁴	>10⁴	328	8565	>10⁴	>10⁴
PDGFRα	657	>10⁴	>10⁴	>10⁴	>10⁴	>10⁴	>10⁴	9.9
RET	11	6584	>10⁴	>10⁴	598	289	>10⁴	433
SRC^a	17	126	303	1040	2453	27	<0.5	<0.5
YES^a	36	71	344	696	566	12	<0.5	<0.5
IC₅₀(ABL) /IC₅₀(SRC)	8	50	25	7	0.5	4	>950	1

Member of SFK.

Table 1. IC50 Values (in nM) Calculated for PP1, 7i–k, 8d, 9d, 11a, and Dasatinib in a Selection of Recombinant Kinases.