. 2015 Dec 10;54(4):531–535. doi: 10.1093/chromsci/bmv177

Table V.

Effect of Flow Rate on the Enantioselectivity of Three Antihistamines

Compound	t_R1	t_R2	α	R_S	Flow rate (mL min⁻¹)
Doxylamine	14.942	15.699	1.09	1.92	0.4
	9.972	10.482	1.09	1.88	0.6
	7.465	7.840	1.09	1.85	0.8
	5.962	6.260	1.09	1.79	1.0
	4.985	5.238	1.09	1.76	1.2
Cetirizine	17.157	20.268	1.29	4.46	0.4
	11.574	13.701	1.29	4.07	0.6
	8.625	10.208	1.29	3.74	0.8
	6.876	6.137	1.28	3.39	1.0
	5.759	6.819	1.29	3.23	1.2
Hydroxyzine	31.543	33.714	1.09	1.91	0.4
	21.566	23.091	1.09	1.83	0.6
	16.382	17.549	1.09	1.74	0.8
	13.042	13.966	1.09	1.66	1.0
	10.952	11.739	1.09	1.59	1.2

Chromatographic conditions. Doxylamine: mobile phase was n-hexane–ethanol (90/10, v/v, 0.1% DEA); cetirizine: mobile phase was n-hexane–isopropanol (60/40, v/v, 0.1% DEA); hydroxyzine: mobile phase was n-hexane–isopropanol (90/10, v/v, 0.1% DEA). The column temperature was at 25°C.