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Effects of graded protectant (0.010–5.0 mM) on viability of APAP-exposed (1.0 mM × 4 hours) isolated mouse hepatocytes. Data are expressed as mean percent of control ± S.E.M. cell viability (n = 6–8). Arrows indicate the first cytoprotectant concentration at which the mean viability data are significantly different from the APAP-alone data. Sequentially higher protectant concentrations were statistically significant. P < 0.05 (level of significance relative to APAP-alone data).
