Skip to main content
. 2016 Jun;357(3):606–618. doi: 10.1124/jpet.116.232009

Fig. 4.

Fig. 4.

Roflumilast treatment of CS-exposed and H1N1-infected mice. (A) CS-exposed and H1N1-infected mice (black bars) were treated with 0.2 mg/kg or 1.0 mg/kg roflumilast (gray bars). White bars show the results from untreated negative control (NC) animals. (B) Body weight loss in NC mice (black dotted line), untreated CS-exposed and H1N1-infected mice (red line), CS-exposed and H1N1-infected mice treated with 0.2 mg/kg (light green line), or 1.0 mg/kg (dark green line) roflumilast. (C) Lung function, resistance, compliance and (D) cytokine levels in lung homogenate (E) total cell, neutrophil, and macrophage numbers in BAL fluid. Mean values ± S.E.M. of n = 7 or 8 animals in the HIN1- and CS-exposed mice groups and n = 4 in the NC group. ****P < 0.0001, ***P < 0.001, **P < 0.01, and *P < 0.05 represent significant differences compared with the CS-exposed and H1N1-infected group.