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. 2015 Dec 2;25(1):54–64. doi: 10.1097/CEJ.0000000000000141

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Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/3.0.

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Fig. 1 — Dietary effects on survival. (a) Kaplan–Meier survival analysis showed that AMPK-activating phytochemicals alone do not produce survival benefit in a melanoma model. The median survival time was not significantly increased after the multiple phytochemical (MP) intervention. (b) Survival benefit was not observed after the low-carbohydrate diet (LCD) intervention either. However, LCD supplemented with a mixture of phytochemicals (LCDmp) significantly increased the median survival time. The median survival time of the control, LCD, and LCDmp groups was 22.80±1.58, 24.69±1.42, and 28.00±1.64 days after inoculation of melanoma cells, respectively. (c) The median survival time of the MCDmp group was also significantly increased compared with that of the MCD and control groups (30.13±2.29, 25.40±1.24, and 23.80±1.08 days, respectively). (d) Tumor size of the MCDmp group was smaller than that of the control group (arrow).