Fig. 1.

Adjusted mean salivary ovarian hormones by high (red line) and low (blue line) percent mammographic density (a, c), absolute mammographic density (b, e), and nondense area (c, f) among 202 premenopausal women. Note that all analyses have used linear mixed models for repeated measures, adjusted for age (continuous), BMI (kg/m²) (continuous), parity (categorical), previous oral contraceptives (categorical), and current smokers (categorical). Mean salivary estradiol throughout the menstrual cycle. (a) Percent mammographic density: ≤28.5%, 16.3 pmol/l; >28.5%, 20.4 pmol/l (P=0.011). (b) Absolute mammographic density: ≤32.4 cm², 17.4 pmol/l; >32.4 cm², 19.4 pmol/l (P=0.148). (c) Nondense area: ≤84.7 cm², 18.9 pmol/l; >84.7 cm², 17.8 pmol/l (P=0.501). Mean salivary progesterone level throughout the menstrual cycle: (d) percent mammographic density: ≤28.5%, 121.8 pmol/l; >28.5%, 140.7 pmol/l (P=0.118). (e) Absolute mammographic density: ≤32.4 cm², 122 pmol/l; >32.4 cm², 140 pmol/l (P=0.092). (f) Nondense area: ≤84.7 cm², 134.9 pmol/l; >84.7 cm², 126.3 pmol/l (P=0.490).