Figure 5.

Fold change distributions in the virtual Leiden Thrombophilia Study (LETS) subject group for the 5 thrombin generation parameters and prothrombin time. For each virtual LETS subject, each parameter, and each acidotic pH level, fold_change = AV/NV if AV > NV and fold_change = NV/AV otherwise, where AV and NV are the acidotic and physiological values of the parameter in that subject, respectively. The plots show distribution histograms generated using the MATLAB function HIST with 100 bins splitting up the interval between 1 and the maximum parameter fold change value for a given pH level. CT = clotting time; PT = thrombin peak time; MS = maximum slope of the thrombin trajectory; PH = thrombin peak height; AUC = area under the thrombin trajectory (or “curve”).