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. 2016 May 5;59(10):4985–4998. doi: 10.1021/acs.jmedchem.6b00308

Figure 2.

Figure 2

(A) Cumulative antinociceptive dose response curves of select benzyl pendant analogues (n = 3 for all analogues) in the mouse WWTW assay following ip administration. Plotted as average ± SEM. ****, p < 0.0001 for 4a and 4h for the 10 mg/kg dose when compared to baseline, p < 0.001 for 4f when compared to baseline (not indicated on graph). (B) Time course of antinociception of 4a and 4h (n = 3) in the mouse WWTW assay following ip administration of 10 mg/kg. Plotted as average ± SEM. Data for 4a from ref (8).