Table 2.
Patient Factors Significantly Associated With Microbiologic Failure and Associated Logistic Regression Model
| Factor | Clearance <4 d (n = 28) |
Clearance ≥4 d (n = 34) |
P Valuea | Odds Ratio | 95% Confidence Interval |
P Value | |||
|---|---|---|---|---|---|---|---|---|---|
| Enterococcus faecium MIC 3–4 µg/mL | 9 | 32.1% | 22 | 64.7% | .011 | 4.701 | 1.371 | 16.118 | .014b |
| E. faecium MIC ≤ 2 µg/mL | 19 | 67.8% | 12 | 35.3% | .011 | ||||
| Immunosuppressionc | 17 | 60.7% | 31 | 91.2% | .004 | 5.318 | 1.201 | 23.54 | .028b |
| Charlson score ≥4 | 16 | 57.1% | 11 | 32.4% | .05 | 0.287 | 0.084 | 0.985 | .047b |
| Congestive heart failured | 11 | 39.3% | 4 | 11.8% | .017 | ||||
| Hemodialysisd | 13 | 46.4% | 7 | 20.6% | .03 | ||||
Data are presented as number, %, unless otherwise specified. Percentages were calculated with outcomes as denominator.
Abbreviation: MIC, minimum inhibitory concentration.
a P values based on χ2, Fisher exact test, or analysis of variance where appropriate.
b Validated by bootstrap analysis.
c Immunosuppression refers to composite of any transplant, neutropenia, immunosuppressive medication use, any steroids, malignancy, and human immunodeficiency virus.
d Clinical factor not included in multivariate analysis due to low number of outcomes or as other clinical factors considered more cogent without overfitting model.