Table 2.
Sedentary Behaviors and Light-Intensity Activities in Relation to Colorectal Cancer Risk in Women and Men
| Hours/week | ||||||
| Sedentary behaviors | 0–6.9 | 7–13.9 | 14–20.9 | ≥ 21 |
Per 7 hours/week increment |
Ptrend |
| Sitting time while watching television | ||||||
| No. of cases | ||||||
| Women | 296 | 289 | 279 | 255 | 1,119 | |
| Men | 309 | 320 | 180 | 104 | 913 | |
| Age-adjusted | ||||||
| Women | 1 | 1.08 (0.91,1.26) | 1.07 (0.91,1.26) | 1.27 (1.07,1.51) | 1.06 (1.02,1.09) | <.01 |
| Men | 1 | 0.99 (0.84,1.16) | 0.98 (0.81,1.18) | 1.12 (0.89,1.41) | 1.02 (0.96,1.08) | .52 |
| Multivariable* | ||||||
| Women | 1 | 1.06 (0.90,1.25) | 1.05 (0.89,1.24) | 1.21 (1.02,1.43) | 1.04 (1.01,1.08) | .01 |
| Men | 1 | 0.97 (0.83,1.14) | 0.94 (0.78,1.14) | 1.06 (0.84,1.34) | 1.00 (0.94,1.07) | .93 |
| Sitting time at work† | ||||||
| No. of cases | ||||||
| Women | 510 | 263 | 152 | 140 | 1,065 | |
| Men | 457 | 107 | 70 | 98 | 732 | |
| Age-adjusted | ||||||
| Women | 1 | 0.98 (0.84,1.13) | 0.86 (0.71,1.03) | 1.12 (0.92,1.35) | 1.01 (0.97,1.05) | .61 |
| Men | 1 | 0.83 (0.67,1.04) | 0.77 (0.59,1.00) | 1.02 (0.80,1.30) | 0.98 (0.92,1.04) | .56 |
| Multivariable* | ||||||
| Women | 1 | 0.98 (0.85,1.14) | 0.87 (0.72,1.04) | 1.14 (0.94,1.38) | 1.01 (0.98,1.05) | .48 |
| Men | 1 | 0.86 (0.69,1.07) | 0.80 (0.61,1.04) | 1.08 (0.84,1.37) | 1.00 (0.94,1.06) | .90 |
| Hours/week | ||||||
| Men only | 0–3.4 | 3.5–7 | 7–13.9 | ≥ 14 |
Per 7 hours/week increment |
Ptrend |
| Sitting time while driving | ||||||
| No. of cases | 406 | 236 | 104 | 25 | 771 | |
| Age-adjusted | 1 | 0.88 (0.75,1.04) | 0.88 (0.70,1.09) | 1.09 (0.72,1.64) | 0.97 (0.85,1.12) | .70 |
| Multivariable* | 1 | 0.89 (0.75,1.05) | 0.88 (0.70,1.09) | 1.04 (0.69,1.58) | 0.97 (0.84,1.11) | .65 |
| Hours/week | ||||||
| Women only | 0–6.9 | 7–13.9 | 14–20.9 | ≥ 21 |
Per 7 hours/week increment |
Ptrend |
| Standing or walking time around at home | ||||||
| No. of cases | 177 | 254 | 244 | 425 | 1,100 | |
| Age-adjusted | 1 | 1.23 (1.01,1.49) | 1.05 (0.86,1.27) | 1.01 (0.85,1.20) | 0.98 (0.96,1.00) | .07 |
| Multivariable* | 1 | 1.26 (1.04,1.53) | 1.09 (0.89,1.32) | 1.06 (0.89,1.27) | 0.98 (0.96,1.01) | .19 |
| Standing or walking time around at work | ||||||
| No. of cases | 408 | 219 | 182 | 265 | 1,074 | |
| Age-adjusted | 1 | 1.05 (0.89,1.24) | 1.01 (0.85,1.21) | 1.03 (0.87,1.22) | 1.01 (0.98,1.04) | .52 |
| Multivariable* | 1 | 1.09 (0.92,1.29) | 1.03 (0.86,1.24) | 1.04 (0.88,1.23) | 1.01 (0.98,1.04) | .48 |
Multivariable analyses were stratified by age (continuous) and questionnaire cycle; adjusted for race (White vs. nonwhite), physical activity (quintiles of MET-hours/week), family history of colon cancer (yes vs. no), personal history of endoscopy and polyps (no endoscopy+no poly detection, endoscopy+no polyp detection, endoscopy+polyp detection), smoking habits (never smoker, 0.1–4.9, 5–19.9, 20–39.9, 40+ pack-years), baseline aspirin use(yes vs. no), current multivitamin use(yes vs. no), intakes of total calorie (quintiles), alcohol (0, 0.1–4.9, 5.0–14.9, ≥15 g/d), red and processed meat (quintiles), fiber (quintiles), total folate at baseline (quintiles), total calcium at baseline (quintiles), total vitamin D (quintiles), and menopausal status and hormone use (women only: premenopausal, postmenopausal never users, postmenopausal past users, postmenopausal current users).
Note: aspirin use, folate intake, and calcium intake were adjusted for using values at the analysis baseline while the rest were adjusted for using cumulative updated values.
In NHS, time spent sitting at work or away from home or driving was used to approximate occupational sitting time.