Table 2.

Results from meta-analyses for all speech and language stimuli. Activation foci obtained from insula responses to language and speech stimuli. Activation likelihood estimate (ALE) values range from a minimum of 0 to a maximum of 1. Greater likelihood of activation in response to stimuli is indicated by higher ALE values. Significant clusters of voxels are listed in order from largest to smallest. Coordinates are in Talairach space (Talairach and Tournoux, 1988).

Stimuli	Side	Insula Region	Cluster #	x	y	z	Volume (mm3)	ALE Value	P value
Receptive Language	Left	anterior	1	−36	16	5	4056	0.02	<0.000001
	Right	anterior	2	33	21	3	2168	0.02	<0.000001
	Right	mid	3	38	−3	16	408	0.01	<0.000001
	Left	anterior	4	−38	−13	11	320	0.01	<0.000001
Expressive Language	Left	anterior	1	−35	11	3	3896	0.02	<0.000001
	Right	anterior	2	31	20	−1	936	0.02	<0.000001
Speech Perception	Left	mid	1	−35	7	10	1896	0.03	<0.000001
	Right	anterior	2	38	9	12	184	0.02	<0.000001
	Right	anterior	3	48	27	21	48	0.01	<0.000001
Speech Production	Left	anterior	1	−35	14	5	3176	0.06	<0.000001
	Right	anterior	2	35	20	8	440	0.03	<0.000001
	Left	anterior	3	−36	6	10	8	0.02	<0.000001