Table 6.

Univariate Cox proportional hazards models for time-to-upgrade by allele counts of iCOGS single nucleotide polymorphisms within active surveillance cohort

	Location	SNP	Hazard ratio	95% CI	p value
SNP 1	11	rs11568818
		0	Reference
		1	3.7	1.71–7.89	<0.001
		2	5.3	2.22–12.70	<0.001
SNP 10	20	rs2427345
		0	Reference
		1	3.1	1.72–5.50	<0.001
		2	3.7	1.41–9.89	0.008
SNP 20	14	rs7141529
		0	Reference
		1	3.1	1.36–7.11	0.007
		2	3.2	1.23–8.23	0.017

CI = confidence interval; SNP = single nucleotide polymorphism.