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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Biochim Biophys Acta. 2016 May 4;1862(8):1433–1442. doi: 10.1016/j.bbadis.2016.05.003

Table 1.

Most up-regulated UPR genes (>2-fold) in the Lop/+ lens (P1 and P7) detected by microarray and validated by qPCR.

Gene symbol P7 fold-change P7 adjusted p-value P7 qPCR fold-change P1 fold-change P1 adjusted p-value P1 qPCR fold-change Mus musculus mRNA transcript Gene ID Alias
Chac1 84.19 6.73E-09 nd 2.03 9.09E-01 nd ChaC, cation transport regulator-like 1 (E. coli) 69065 Botch
Ddit3 11.81 1.38E-05 12.25 1.28 8.20E-01 1.66 DNA-damage inducible transcript 3 13198 Chop, Gadd153
Atf3 5.18 1.59E-04 nd 2.90 2.09E-02 nd Activating transcription factor 3 11910
Trib3 4.70 1.23E-04 nd 1.10 9.62E-01 nd Tribbles homolog 3 (Drosophila) 228775
Xbp1 4.15 9.09E-07 3.76 1.55 2.12E-01 1.37 X-box binding protein 1 22433
Dnajb9 3.02 2.17E-04 5.83 1.42 6.37E-01 2.03 Dnaj (Hsp40) homolog, subfamily B, member 9 27362
Cebpb 2.50 8.75E-03 5.14 1.50 2.19E-02 1.44 CCAAT/enhancer binding protein (C/EBP), beta 12608
Herpud1 2.08 5.05E-04 2.03 1.06 9.83E-01 1.27 Homocysteine-inducible, ER stress-inducible, ubiquitin-like domain member 1 64209
Insig1 1.47 8.70E-03 2.26 4.79 8.64E-01 -1.19 Insulin induced gene 1 231070
Hspa5 nd nd 2.55 nd nd 1.13 Heat shock protein 5 14828 Grp78, Bip