Table 1.
Most up-regulated UPR genes (>2-fold) in the Lop/+ lens (P1 and P7) detected by microarray and validated by qPCR.
| Gene symbol | P7 fold-change | P7 adjusted p-value | P7 qPCR fold-change | P1 fold-change | P1 adjusted p-value | P1 qPCR fold-change | Mus musculus mRNA transcript | Gene ID | Alias |
|---|---|---|---|---|---|---|---|---|---|
| Chac1 | 84.19 | 6.73E-09 | nd | 2.03 | 9.09E-01 | nd | ChaC, cation transport regulator-like 1 (E. coli) | 69065 | Botch |
| Ddit3 | 11.81 | 1.38E-05 | 12.25 | 1.28 | 8.20E-01 | 1.66 | DNA-damage inducible transcript 3 | 13198 | Chop, Gadd153 |
| Atf3 | 5.18 | 1.59E-04 | nd | 2.90 | 2.09E-02 | nd | Activating transcription factor 3 | 11910 | |
| Trib3 | 4.70 | 1.23E-04 | nd | 1.10 | 9.62E-01 | nd | Tribbles homolog 3 (Drosophila) | 228775 | |
| Xbp1 | 4.15 | 9.09E-07 | 3.76 | 1.55 | 2.12E-01 | 1.37 | X-box binding protein 1 | 22433 | |
| Dnajb9 | 3.02 | 2.17E-04 | 5.83 | 1.42 | 6.37E-01 | 2.03 | Dnaj (Hsp40) homolog, subfamily B, member 9 | 27362 | |
| Cebpb | 2.50 | 8.75E-03 | 5.14 | 1.50 | 2.19E-02 | 1.44 | CCAAT/enhancer binding protein (C/EBP), beta | 12608 | |
| Herpud1 | 2.08 | 5.05E-04 | 2.03 | 1.06 | 9.83E-01 | 1.27 | Homocysteine-inducible, ER stress-inducible, ubiquitin-like domain member 1 | 64209 | |
| Insig1 | 1.47 | 8.70E-03 | 2.26 | 4.79 | 8.64E-01 | -1.19 | Insulin induced gene 1 | 231070 | |
| Hspa5 | nd | nd | 2.55 | nd | nd | 1.13 | Heat shock protein 5 | 14828 | Grp78, Bip |