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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Trends Mol Med. 2016 May 10;22(6):458–478. doi: 10.1016/j.molmed.2016.04.003

Figure 2. Antibiotic-Mediated Microbiota Depletion Causes Disease in Multiple Organs.

Figure 2

Antibiotics act on the gut microbiota by decreasing its density and modifying its composition in a long-lasting fashion. This causes reduced signaling to the intestinal mucosa and peripheral organs, which results in impaired functioning of the immune system. Depicted are examples of diseases that were shown to arise or be worsened as a consequence of antibiotic treatment in mouse models (see main text).