Table 2.
Associations of ADH1B and ALDH2 polymorphisms with fasting blood glucose levels in men and women
| Genotype | Men | Women | ||||||
|---|---|---|---|---|---|---|---|---|
| N | Crude mean(SE) | Adjusted mean (SE) b | Adjusted mean (SE) c | N | Crudemean (SE) | Adjusted mean (SE) b | Adjusted mean (SE) c | |
| ADH1B Arg48His a | ||||||||
| His/His | 515 | 98.2 (0.5) | 98.3 (0.5) | 98.2 (0.5) | 514 | 92.4 (0.5) | 92.7 (0.4) | 92.6 (0.4) |
| Arg/His | 338 | 99.0 (0.6) | 98.3 (0.6) | 98.2 (0.6) | 343 | 94.0 (0.6) | 93.2 (0.5) | 93.2 (0.5) |
| Arg/Arg | 54 | 99.6 (1.6) | 99.0 (1.5) | 99.4 (1.7) | 52 | 95.2 (1.5) | 93.1 (1.2) | 92.9 (1.3) |
| P-value d | 0.51 | 0.89 | 0.75 | 0.04 | 0.69 | 0.66 | ||
| ALDH2 Glu504Lys a | ||||||||
| Glu/Glu | 499 | 99.9 (0.5) | 99.2 (0.5) | 99.1 (0.5) | 547 | 93.6 (0.5) | 92.9 (0.4) | 92.8 (0.4) |
| Glu/Lys | 337 | 97.7 (0.6) | 97.8 (0.6) | 97.8 (0.6) | 311 | 92.9 (0.6) | 93.2 (0.5) | 93.3 (0.5) |
| Lys/Lys | 71 | 93.9 (1.4) | 95.4 (1.3) | 95.6 (1.3) | 53 | 90.5 (1.5) | 90.9 (1.2) | 91.1 (1.2) |
| P-value d | < 0.0001 | 0.01 | 0.04 | 0.23 | 0.13 | 0.21 | ||
N, number; SE, standard error.
a) The genotype was not determined for three subjects for ADH1B and one subject for ALDH2.
b) Adjusted for age, area, body mass index, smoking, coffee consumption, physical activity, and parental diabetes mellitus.
c) Adjusted for age, area, body mass index, smoking, alcohol consumption, coffee consumption, physical activity, and parental diabetes mellitus.
d) Analysis of variance or covariance for means.