Figure 1.

Schematic representation of main effects of CB₂ receptor activation reported in AD models. CB₂ receptor agonists reduce the release of pro-inflammatory molecules, facilitate Aβ clearance by promoting microglia phagocytic phenotype, reduce Aβ neurotoxicity, and facilitate glucose uptake. Moreover, CB₂-mediated activity reduces oxidative stress damage produced by reactive oxidative species (ROS) and tau hyper-phosphorylation.