Figure 5.

Certain pre-miRNAs had signatures corresponding to the cleavage sites of their own and other mature miRNAs. (A) The pre-miRNAs cleaved by their own mature miRNAs. The precursors of ptc-miR396a, ptc-miR396b, and ptc-miR1450 were cleaved by their own mature mRNAs at position 10 of the miRNA^* region. (B) The pre-miRNAs cleaved by other mature miRNAs. The precursors of ptc-miR396a and ptc-miR396d were cleaved by ptc-miR396e-3p at the cleavage sites of mature miRNAs; the precursors of pto-miR047a and pto-miR185 were targeted by ptc-miR169q and pto-miR170, respectively, at cleavage sites in the loop-forming region; and the precursors of pto-miR025a, b and pto-miR185 were targeted by pto-miR175 and pto-miR080, respectively, at cleavage sites located near the 5′ end of the mature miRNAs. The mature miRNAs are underlined. The miRNAs^* are presented in red, and the complementary regions of mature miRNAs are shown in green. The lowercase letters and red arrows indicate the cleavage sites of miRNAs.